An American Vein is an anthology of literary criticism of Appalachian novelists, poets, and playwrights. The book reprises critical writing of influential authors such as Joyce Carol Oates, Cratis Williams, and Jim Wayne Miller. It introduces new writing by Rodger Cunningham, Elizabeth Engelhardt, and others.

Many writers from the mountains have found success and acclaim outside the region, but the region itself as a thriving center of literary creativity has not been widely appreciated. The editors of An American Vein have remedied this, producing the first general collection of Appalachian literary criticism. This book is a resource for those who teach and read Appalachian literature. What's more, it holds the promise of introducing new readers, nationally and internationally, to Appalachian literature and its relevance to our times.