Glyphosate is a popular global post-emergent perennial herbicide. This volume is a comprehensive review of glyphosate's history, properties, chemistry, biology, formulation, technology, enzymology, and structure/activity relationship. The discussion covers glyphosate's unique environmental properties, broad range of application, soil inactivity, soil and plant metabolism, low toxicity, and uptake and transport in plants. It also covers the syntheses of hundreds of analogs and derivatives and clarifies glyphosate's molecular mode of action and its effect on the target enzyme EPSP synthase.