The central theme of this work is Jung's concept of synchronicity. This exploration of the scientific basis for meaningful coincidence interweaves the author's interpretation of synchronicity with key concepts in quantum physics and the basic tenets of Middle Way Buddhism.

The pioneering analysis of synchronicity was given by Jung, yet despite the concept's momentous significance in Jung's work, and despite the widespread dissemination of the term 'synchronicity' even within pop culture, synchronicity is often badly misconstrued and remains "perhaps the least understood of Jung's theories". Synchronicity, Science, and Soul-Making has already been hailed as the most important analysis of synchronicity since Jung himself.