This volume consists of the scientific work presented at the 14th Regional Conference on Mathematical Physics, held in November 2015 in Islamabad, Pakistan, and dedicated to the memory of Riazuddin, the first Pakistani PhD student of the late Nobel laureate, Abdus Salam, and one of the pioneers who developed physics in Pakistan. This collection surveys the latest developments in a wide area of mathematical physics as presented by world-renowned experts. The contributors sample a number of topics including the formal aspects of mathematical physics, general relativity and cosmology, particle physics, astrophysics, string theory, black hole physics, quantum gravity, quantum field theory, condensed matter physics, symmetries in mathematics and physics, and even applied physics.