This book is based on the first five years of The Dr. Bo Show, where Bo takes a critical thinking-, reason-, and science-based approach to issues that matter with the goal of educating and entertaining. Every chapter in the book explores a different aspect of reason by using a real-world issue or example. Part one is about how science works even when the public thinks it doesn't. Part two will certainly ruffle some feathers by offering a reason- and science-based perspective on issues where political correctness has gone awry. Part three provides some data-driven advice for your health and well-being. Part four looks at human behavior and how we can better navigate our social worlds. In part five we put on our skeptical goggles and critically examine a few commonly-held beliefs. In the final section, we look at a few ways how we all can make the world a better place.