With great power comes…great frustration! After seeing a bigger transformation during their "change of life" than they ever expected, Patricia, Jessica, and Linda/Leonel are adjusting (sorta) to life as superheroes. Retired executive Patricia O'Neill is hard at work looking for the woman responsible for their newfound circumstances, while Jessica and Linda/Leonel are training with a covert agency called The Department. Patricia wants to track down the mad scientist, while Jessica and Leonel want to use their newfound powers for the greater good. Are they being used, like Patricia thinks? Or is she just frustrated because her search is stalled? Then Patricia disappears, and all the clues point to a dead man. Now it's up to the Menopausal Superheroes and their colleagues at The Department to find their friend and bring her home.