During the Covid-19 pandemic, award-winning author and artist Mario Acevedo chronicled life in lockdown with a daily cartoon. Cats in Quarantine, a single-panel comic, appeared every day on Acevedo's social media, and every day, it drew more fans. As the days and weeks stretched to months and years, these sketches became more than a pastime for Acevedo, more than a touchstone for his friends. They became an incisive record of a historical turning point. From toilet paper and vaccines to political pique and social unrest, Cats in Quarantine captured the zeitgeist of the Covid era with Acevedo's signature humor and keen, observant intelligence. This collection of 300 Cats in Quarantine favorites commemorates the tragic and the absurd, the frustrations, fear, and loss that marked a time we might want to forget, but one humanity would do well to remember.