Nightclub singer Margaret Odell, the famous Broadway beauty and ex-Follies girl known as "The Canary", is found murdered in her ransacked apartment, her jewelry stolen. It appears at first to be a robbery gone wrong, but the police can find no physical evidence to pinpoint a culprit. No one witnessed anyone entering or leaving, and the only unwatched entrance to the apartment building was bolted from the inside.

Who could have killed the Canary in her locked cage? The victim was seeing a number of men, ranging from a high society gentleman to ruthless gangsters, and more than one man visited her apartment on the night she died. When the D.A. is stumped, he turns to his friend Philo Vance, an erudite and snobbish aristocrat, who applies his brilliant observations of human nature during a poker game with the suspects to determine who in fact knocked the Canary from her perch-permanently.