Patients undergoing endodontic treatment may develop post-endodontic pain, leading to pain and inflammation. Cryotherapy is a remedial procedure widely used in the field of medicine and dentistry, considered to be effective at reducing edema, pain, bleeding and inflammation. In endodontics, it is relatively new and may be beneficial in the prevention and treatment of post-endodontic pain.Additionally, cryogenic treatment is considered a key factor in strengthening rotary NiTi endodontic files. Further well-designed clinical studies will be conducted to establish the effective use of cryotherapy in the control of post-endodontic pain in clinical practice. This book describes the concept of cryotherapy and its potential clinical implications in endodontics.