"The Descartes Lectures" is a biennial event at Tilburg University that invites a distinguished philosopher to deliver a series of three lectures, each followed by commentaries from other experts in the field. In 2022, Tilburg University had the honor of hosting Cheshire Calhoun for a series of talks on the important philosophical question of what it means to be a responsible person. The commentators for the lectures were Gunnar Björnsson, Jules Holroyd, and Heidi Maibom. This book is a compilation of the material of Calhoun's lectures, the commentaries by Björnsson, Holroyd, and Maibom, as well as Calhoun's replies to their critiques.