This book, International Conference in Information Systems and Medicine, Volume 2, is part of the Lecture Notes in Networks and Systems series and features a selection of the best papers accepted for presentation and discussion at the 2026 International Conference in Information Systems and Medicine (ICISMED26). Held from 26 to 28 March 2026, ICISMED26 is a multidisciplinary conference with a particular focus on emerging technologies and systems in the healthcare sector. The event was supported by the Autonomous University of Chile in Temuco and the International Association for Digital Transformation and Technological Innovation (IADITI).

This book is intended for researchers, academics, lecturers, specialists, professionals, doctoral and master's students, undergraduates, and practitioners working at the intersection of healthcare and information technologies. This book addresses foundational and advanced concepts related to the paradigm of intelligent computing and communication within the context of distributed computing, big data, high-performance computing, and the Internet of Things (IoT), specifically applied to healthcare.

Given the critical need to develop adaptive, intelligent, energy-efficient, secure, and privacy-aware mechanisms in high-performance and IoT-based healthcare applications, this book serves as both a practical reference for industry professionals and a foundational guide for beginners. It facilitates understanding from basic principles to advanced practices in computing paradigms and their application to healthcare challenges.

Global health research increasingly prioritizes responsive strategies to the rapid changes reshaping our world-technological, political, social, cultural, educational, and economic-all of which impact healthcare delivery and systems. This publication provides an opportunity for academics and practitioners from diverse health-related fields to build bridges of knowledge, encourage research, and support the ongoing evolution of healthcare systems.